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ea0075d24 | Diabetes | EYES2021

Sex-specific cardioprotection of daily tadalafil in patients with type-2 diabetes. The RECOGITO, randomized, double-blind, placebo-controlled trial

Pofi Riccardo , Giannetta Elisa , Feola Tiziana , Galea Nicola , Campolo Federica , Barbagallo Federica , Badagliacca Roberto , Barbano Biagio , Ciolina Federica , Defeudis Giuseppe , Filardi Tiziana , Sesti Franz , Minnetti Marianna , Dario Vizza Carmine , Pasqualetti Patrizio , Carbone Iacopo , Francone Marco , Catalano Carlo , Pozzilli Paolo , Lenzi Andrea , Venneri Mary Anna , Gianfrilli Daniele , Isidori Andrea M.

Background: Cyclic GMP-phosphodiesterase type 5(PDE5) inhibition was shown to counteract maladaptive cardiac changes triggered by diabetes in some, but not all studies.Objective: To assess sex differences in cardiac remodeling after PDE5 inhibition in patients with diabetic cardiomyopathy.Methods: 20-week, double-blind, randomized, placebo-controlled trial (NCT01803828). 220 men and women (45-80 years) with long-duration (>3 ye...

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ea0056gp34 | Adrenal cortex | ECE2018

Effects of replication of the physiological and non-physiological cortisol rhythm on insulin sensitivity in muscle: a molecular in vitro analysis on synchronized muscular cells

Negri Mariarosaria , Di Gennaro Gilda , Pivonello Claudia , Simeoli Chiara , Vennery Mary Anna , Barbagallo Federica , Iacuaniello Davide , De Martino Maria Cristina , Isidoro Andrea Maria , Colao Annamaria , Pivonello Rosario

Adrenal insufficiency is a rare endocrine disorder characterized by low levels of cortisol associated with increased mortality, also due to inadequate replacement therapy. The replacement with the thrice-daily immediate release hydrocortisone (IRH), in contrast to the once-daily modified-release hydrocortisone (MRH), more appropriately mimicking the physiological circadian rhythm of cortisol (PCRC), is associated with metabolic disorders, mainly due to the non-physiological pe...

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Endocrine Abstracts

Sex-specific cardioprotection of daily tadalafil in patients with type-2 diabetes. The RECOGITO, randomized, double-blind, placebo-controlled trial

Effects of replication of the physiological and non-physiological cortisol rhythm on insulin sensitivity in muscle: a molecular in vitro analysis on synchronized muscular cells

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